发明名称 |
BENZONATATE MODIFIED RELEASE SOLID TABLETS AND CAPSULES |
摘要 |
A 12-hour anti-tussive modified release solid tablet or capsule is described which comprises a benzonatate in a matrix with a sufficient amount of one or more pharmaceutically acceptable modified release pH-independent, substances to provide a 12-hour modified release profile to the benzonatate, wherein there is substantially no benzonatate release from the tablet or capsule in the buccal cavity and no more than about 25% release of the benzonatate within 1 hour as determined in an in vitro dissolution assay. The modified release may be provided by (a) a high melt temperature, water-insoluble wax or waxy substance, (b) a low viscosity hydrophilic polymer such a hydroxypropyl methylcellulose, (c) a reverse enteric coating, or combinations thereof. The benzonatate may be in an adsorbate with a silico or silicate or in a complex with a weak acidic ion exchange resin complex. |
申请公布号 |
WO2014159340(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
WO2014US23106 |
申请日期 |
2014.03.11 |
申请人 |
TRIS PHARMA, INC. |
发明人 |
NELSON, ANDREA;CHEN, QUIN-ZENE;METHTA, HARSH;TU, YU-HSING |
分类号 |
A61K9/14;A61K9/16;A61K9/20;A61K9/24;A61K9/28;A61K9/50;A61K31/09;A61K31/216 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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