发明名称 |
RADIOLABELED ANTI-GLYPICAN-3 IMMUNOCONJUGATES FOR IMMUNO-PET IMAGING OF HEPATOCELLULAR CARCINOMA |
摘要 |
<p>Provided are immunoconjugate probes useful for detecting hepatocellular carcinoma (HCC) lesions. The probes comprise a glypican-3 (GPC3)-specific monoclonal antibody or fragment thereof conjugated to a radionuclide such as 89Zr, 64Cu, and the like. The probes are useful for obtaining PET images with high tumor-to-liver ratios and targeting for diagnostic imaging of HCC lesions or cells in vitro and in vivo.</p> |
申请公布号 |
WO2014159087(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
WO2014US21898 |
申请日期 |
2014.03.07 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
CHENG, ZHEN;CHUA, MEI-SZE;SO, SAMUEL;YANG, XIAOYANG |
分类号 |
A61K38/17;A61K31/00;A61K48/00 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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