发明名称 |
IN VITRO DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO PANCREATIC ENDODERM CELLS (PEC) AND ENDOCRINE CELLS |
摘要 |
A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation. |
申请公布号 |
CA2897984(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
CA20142897984 |
申请日期 |
2014.03.13 |
申请人 |
VIACYTE, INC. |
发明人 |
AGULNICK, ALAN;D'AMOUR, KEVIN |
分类号 |
C12N5/0735 |
主分类号 |
C12N5/0735 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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