发明名称 |
IMPROVED METHOD FOR PRODUCING FACTOR H FROM A PLASMA PRECIPITATION FRACTION |
摘要 |
<p>The present disclosure provides, among other aspects, improved methods for the manufacture of Factor H compositions from plasma precipitation fractions. In some aspects, the methods include an improved process step for extracting Factor H from a plasma precipitate fraction with reduced co-extraction of amidolytic activities. In other aspects, the methods include a heat treatment step for reducing impurities, such as amidolytic enzymes, from a Factor H composition. In yet other aspects, the methods include improved anion exchange, heparin affinity, and/or mixed mode chromatographic enrichment of Factor H. In still other aspects, the improved methods include a combination of the individual improved process steps disclosed herein.</p> |
申请公布号 |
AU2013202965(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
AU20130202965 |
申请日期 |
2013.04.08 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A. |
发明人 |
TESCHNER, WOLFGANG;MADLENER, RUTH;SCHWARZ, HANS-PETER;SVATOS, SONJA;PLJEVLJAKOVIC, AZRA;NITSCH, LENA |
分类号 |
C07K1/16;C07K1/30;C07K1/36 |
主分类号 |
C07K1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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