| 主权项 |
1. A method of treating cancer in a patient, comprising administering to the patient an effective amount of (a) a compound of formula IA: or a metabolite or a pharmaceutically acceptable salt thereof; wherein:
R1 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl;R2 is hydrogen or alkyl;R4 is alkyl;R5 is hydrogen; andR6 is phenyl, acyl, or heteroaryl wherein the phenyl and heteroaryl are is optionally substituted with 1, 2, 3, 4, or 5 R9 groups; andeach R9, when present, is independently halo, alkyl, haloalkyl, alkoxy, haloalkoxy, cyano, amino, alkylamino, dialkylamino, alkoxyalkyl, carboxyalkyl, alkoxycarbonyl, aminoalkyl, cycloalkyl, aryl, arylalkyl, aryloxy, heterocycloalkyl, or heteroaryl and where the cycloalkyl, aryl, heterocycloalkyl, and heteroaryl, each either alone or as part of another group within R9, are independently optionally substituted with 1, 2, 3, or 4 groups selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, amino, alkylamino, and dialkylamino,wherein the cancer is selected from the group consisting of relapsed or refractory NHL, MCL, FL, CLL/SLL, and DLBCL. |
