AMIDE PROTON TRANSFER (APT) AND ELECTRIC PROPERTIES TOMOGRAPHY (EPT) IMAGING IN A SINGLE MR ACQUISITION

摘要

The present invention relates to a magnetic resonance imaging, MRI, system (200) for acquiring magnetic resonance data from a target volume in a subject (218), the MRI system (200) comprising a memory (236) for storing machine executable instructions; and a processor (230) for controlling the MRI system (200), wherein execution of the machine executable instructions causes the processor (230) to use a first MRI sequence (401) containing a first selective RF pulse (413) followed by a first excitation RF pulse (415) to control the MRI system (200) to selectively excite and saturate exchangeable amide protons within a first frequency range in the target volume; irradiate said target volume with the first excitation RF pulse (415) that is adapted to excite bulk water protons in the target volume; and acquire first magnetic resonance imaging data from the target volume in response to the first excitation RF pulse (415); use a second MRI sequence (403) containing a second selective RF pulse (423) followed by a second excitation RF pulse (425) to control the MRI system (200) to selectively excite and saturate the exchangeable amide protons within a second frequency range in the target volume; irradiate said target volume with the second excitation RF pulse (425) that is adapted to excite said bulk water protons; and acquire second magnetic resonance imaging data from said target volume in response to the second excitation RF pulse (425); wherein the first MRI sequence (401) comprises gradients (417) having first gradient polarities reverse of second gradient polarities (427) of the second MRI sequence (403).