FORMULATIONS BASED ON SOLID DISPERSIONS

摘要

The present invention relates to formulations comprising a solid dispersion product of an active agent having at least one of a hydrogen bond donor moiety (e.g. ibuprofen, fenofibric acid or naproxen) and a proton donor moiety and a pharmaceutically acceptable polyvinyllactam polyvinylacetate poly(alkylene glycol) graft copolymer, and to methods for preparing such formulations.

主权项

1. A formulation comprising a solid dispersion product comprising
(a) an active agent having at least one of a hydrogen bond donor moiety and a proton donor moiety, (b)a pharmaceutically acceptable polyvinyllactam polyvinylacetate poly(alkylene glycol) graft copolymer, and (c) a pharmaceutically acceptable pH modifier; wherein the active agent is selected from pharmaceutically active agents, cosmetically active agents and nutritional supplements, and is a compound with a solubility in water at 25° C. and pH 7.0 of 0.01 g/100 ml or less.