GAMMA SECRETASE MODULATORS

摘要

Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and use of the compounds in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.;

主权项

1. A compound of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is 1) hydrogen, 2) (C1-C6)alkyl optionally substituted with 1 to 5 halogens or phenyl, wherein the phenyl is optionally substituted with 1 to 3 halogens, 3) phenyl optionally substituted with 1 to 3 (C1-C6)alkyls or 1 to 5 halogens, or 4) (C4-C6)cycloalkyl optionally substituted with 1 to 3 (C1-C6)alkyls or 1 to 5 halogens; R2 is 1) hydrogen, 2) (C1-C6)alkyl optionally substituted with 1 to 5 halogens or phenyl, wherein the phenyl is optionally substituted with 1 to 3 halogens, or 3) phenyl optionally substituted with 1 to 3 halogens; R3 is (C1-C6)alkyl, —OH or halogen; X is —NR4—, —O—, —S—, or —SO2—; R4 is hydrogen or (C1-C3)alkyl; p is 1 to 3; m is 0 or 1; n is 0 to 3; and Ar2—Ar1 is selected from the group consisting of