发明名称 |
HUMANIZED LIGHT CHAIN MICE |
摘要 |
<p>Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin lambda light chain variable domain.</p> |
申请公布号 |
KR20140116135(A) |
申请公布日期 |
2014.10.01 |
申请号 |
KR20147020454 |
申请日期 |
2012.12.17 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MACDONALD LYNN;GURER CAGAN;HOSIAWA KAROLINA A.;STEVENS SEAN;MURPHY ANDREW J. |
分类号 |
A01K67/027;C07K16/46;C12N5/0781;C12N9/64;C12P21/08 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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