发明名称 |
METHOD FOR SYNTHESIZING HYDROXY-BISPHOSPHONIC ACID DERIVATIVES |
摘要 |
The present invention relates to a method for preparing a hydroxy-bisphosphonic acid derivative or a salt thereof, from the corresponding carboxylic acid, comprising the following steps: - activation of the carboxylic acid function in the form of the boronate derivative thereof through the action of a borane, then - reaction with tris(trimethyl-silyl)phosphite, under Arbuzov conditions - treatment with an alcohol, chosen in particular from an aliphatic alcohol or trifluoromethanol, and - separation of the hydroxy-bisphosphonic acid derivative formed, from the reaction medium. |
申请公布号 |
EP2240500(B1) |
申请公布日期 |
2014.10.01 |
申请号 |
EP20090700083 |
申请日期 |
2009.01.05 |
申请人 |
UNIVERSITÉ DE NANTES;CHU NANTES;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
EGOROV, MAXIM;FORTUN, YANNICK;HEYMANN, DOMINIQUE;LEBRETON, JACQUES;MATHE, MONIQUE;PADRINES, MARC;REDINI, FRANÇOISE |
分类号 |
C07F9/38 |
主分类号 |
C07F9/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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