Fluoroform synthesis and uses thereof in the preparation of trifluoromethylated compounds

摘要

The present invention relates to a process to prepare fluoroform (CHF 3 ), notably radio labelled with fluorine-18, comprising a substitution reaction between CHAF 2 and a fluoride salt,
wherein A represents
or
as well as a process to prepare a composition comprising copper-based or silver-based trifluoromethylated reagents using notably the fluoroform thus prepared and the use of a composition comprising copper-based trifluoromethylated reagents or a mixture comprising a copper salt and a composition comprising silver-based trifluoromethylated reagents as a trifluoromethylating agent, notably radio labelled with fluorine-18.