| 发明名称 | Natural combination hormone replacement formulations and therapies | ||
| 摘要 | Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone. | ||
| 申请公布号 | US8846649(B2) | 申请公布日期 | 2014.09.30 |
| 申请号 | US201314099571 | 申请日期 | 2013.12.06 |
| 申请人 | TherapeuticsMD, Inc. | 发明人 | Bernick Brian A.;Cacace Janice Louise;Persicaner Peter H. R.;Irani Neda;Amadio Julia M. |
| 分类号 | A01N45/00;A61K9/48;A61K9/16;A61K31/57;A61K31/565 | 主分类号 | A01N45/00 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP ;Walker Marlan D. |
| 主权项 | 1. A pharmaceutical composition comprising: solubilized estradiol; suspended progesterone; and a solubilizing agent; wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed; wherein at least about 90% of the estradiol is solubilized in the solubilizing agent; and wherein the solubilizing agent comprises an effective amount of at least one of mono-, di-, and triglycerides containing an ester of a C6-C12 fatty acid. | ||
| 地址 | Boca Raton FL US | ||