TARGETED SUSTAINED-RELEASE MICROSPHERE OF VASCULAR OCCLUSIVE AGENT CONTAINING SODIUM ALGINATE AND SORAFENIB, PRODUCTION METHOD AND USE THEREOF

摘要

A targeted sustained-release microsphere vascular embolizing agent, the production method and the use thereof are disclosed. The microsphere comprises sodium alginate as the carrier and sorafenib as the targeted anti-tumor medicine and sorafenib is encapsulated by sodium alginate. The weight ratio of sorafenib to sodium alginate is 1:1-1:30. The microspheres are used for manufacturing medicament for the treatment of solid tumors with advantages including high medicine concentration in the target regions with reduced systemic dosage and toxic and side effects.