Diagnostic nanosensor and its use in medicine

摘要

This invention relates generally to biosensor technology, and pertains more particularly to novel multifunctional biosensors based on ordered arrays of metallic, semiconductors and magnetic nano-islands for medical, biological, biochemical, chemical and environmental applications.

主权项

1. A method for producing a Diagnostic-Nanosensor having a carrier and two-dimensioned arched metallic nanostructures with detection-molecules, the method comprising:
assembling said Diagnostic-Nanosensor on a spring wire or stent to form a molecular or cell select catheter configured for obtaining molecular or cellular components directly from intravenous blood circulation; configuring said Diagnostic-Nanosensor to be applied through a hollow needle or through a venous line into a human blood vessel so that, when in use, the Diagnostic-Nanosensor can be retracted with attached cells and/or molecules for processing after an incubation time; patterning the metallic nanostructures as periodic, surface-confined nanotriangles forming nanopatterned islands disposed in a hexagonal array, characterized by surface-confined rod-shaped horizontal nano-morphologies obtained by a sintering process of the surface-confined nanotriangles, wherein the nanopatterned islands are obtained by nanosphere lithography (NSL) with an annealing step of a polystyrene mask; and linking bio-organic interactive material to the nanostructures indirectly through linker technology.