Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer

摘要

Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovarian tumor inhibiting compositions that include extracellular matrix tissue adjuvants.

主权项

1. A method for eliciting an immune response against ovarian cancer comprising administering a cellular preparation comprising non-viable ovarian tumor tissue and an ovarian tissue adjuvant to a patient in need thereof, wherein the non-viable ovarian tumor tissue comprises both ovarian tumor cells and non-tumor tissue, and wherein the ovarian tissue adjuvant is an extracellular matrix from a non-tumor tissue source.