METHOD FOR MANUFACTURING OF HYALURONIC ACID AND THE COMPOSITION FOR ANTI ADHESION COMPRISING THE HYALURONIC ACID BY THE SAME METHOD

摘要

The present invention relates to a method for manufacturing hyaluronic acid having low dissolving speed in the body and a composition for adhesion prevention comprising hyaluronic acid manufactured thereby. More specifically provided are a method for manufacturing hyaluronic acid having low dissolving speed in the body including a step for cultivating streptococcus dysgalactiae ID9103 strains (KCTC11818BP) in a culture ground where carbon source and nitrogen source are included and a composition for adhesion prevention comprising hyaluronic acid manufactured thereby. Hyaluronic acid manufactured by the manufacturing method of the present invention has an excellent effect in adhesion prevention due to having low dissolving speed in the body as 4 million Da to 10 million Da of highly polymerized hyaluronic acid. A composition of the present invention for adhesion prevention comprising hyaluronic acid manufactured by the manufacturing method of the present method can ameliorate problems of the existing composition for adhesion prevention including cross-linker and compound and problems of the existing hyaluronic acid.