主权项 |
1. Compounds of formula (I) wherein: W1, W2, W3 denote CR3, or W1, W2 denote CR3, and W3 denotes N, R1 phenyl optionally substituted by at least one substituent selected from the group consisting of Hal and CF3, R2 denotes Ar, Het1, Het2, NH-Het1 or NH-Het2, each of which can be independently from each other substituted by R4, R3 denotes H, NYY or NY—COY, R4 denotes Hal, A, —(CYY)n—OY, —(CYY)n—NYY, (CYY)n-Het3, (CYY)n—O-Het3, SY, NO2, CF3, CN, COOY, —CO—NYY, —NY—COA, —NY—SO2A, —SO2—NYY, S(O)mA, —CO-Het3, —O(CYY)n—NYY, —O(CYY)n-Het3, —NH—COOA, —NH—CO—NYY, —NH—COO—(CYY)n—NYY, —NH—COO—(CYY)n-Het3, —NH—CO—NH—(CYY)n—NYY, —NH—CO—NH(CYY)n-Het3, —OCO—NH—(CYY)n—NYY, —OCO—NH—(CYY)n-Het3, CHO, COA, ═S, ═NY, ═O, Y denotes H, A denotes unbranched or branched alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, in which 1, 2, 3, 4, 5, 6 or 7H atoms can be replaced independently from one another by Hal and/or one or two CH2 groups can be replaced independently of one another by a O, S, SO, SO2, a —CY═CY— group and/or a —C≡C— group, Ar denotes a saturated, unsaturated or aromatic, mono- or bicyclic carbocycle having 5, 6, 7, 8, 9, or 10 C atoms, Het1 denotes a saturated or unsaturated, mono, or bicyclic heterocycle having 3, 4, 5, 6, 7, 8, or 9 C atoms and 1, or 2 atoms, Het2 denotes a mono, or bicyclic heteroaryl having 3, 4, 5, 6, 7, 8, or 9 C atoms and 1, or 2 atoms, Het3 denotes a saturated or unsaturated, mono or bicyclic heterocycle having 3, 4, 5, 6, 7, 8, or 9 C atoms and 1 or 2 N and/or O atoms, which can independently from each other be substituted by at least one substituent selected from the group consisting of A, Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, n denotes 0, 1, 2, 3 or 4, and the physiologically acceptable salts, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. |