Method for determining the concentration of the adipocytic form of the fatty acid binding protein (A-FABP, FABP4, P2)

摘要

Products and methods for the research, diagnosis, risk assessment, course monitoring, treatment and prophylaxis of various metabolic disorders and their early forms, concomitant diseases and secondary diseases are provided. Metabolic diseases include, for example, metabolic syndrome, non-insulin-dependent diabetes, (type II diabetes), insulin resistance, obesity (adiposis), in addition to diseases that are associated with disorders of the fatty acid metabolism. Methods may include analysis of the concentration of the adipocytic form of the fatty acid binding protein (A-FABP, FABP 4, P2) in various bodily fluids.

主权项

1. A method for the diagnosis of metabolic syndrome, comprising:
obtaining a sample of human serum or plasma from a subject suspected of having a metabolic syndrome, measuring a concentration of the adipocytic form of a fatty acid binding protein (A-FABP) in said human serum or plasma from said subject suspected of having a metabolic syndrome, including the step of immobilizing the A-FABP on an immobilization medium, wherein the immobilization medium is selected from the group consisting of gold and a gold coated surface, and diagnosing metabolic syndrome on the basis of the measured concentration of A-FABP, wherein the diagnosis is positive if said concentration is elevated relative to a baseline level.