| 发明名称 | Disease risk factors and methods of use | ||
| 摘要 | Provided herein are genetic variants associated with development of a condition of interest (e.g., Alzheimer's disease). Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene. | ||
| 申请公布号 | US8846315(B2) | 申请公布日期 | 2014.09.30 |
| 申请号 | US201113029713 | 申请日期 | 2011.02.17 |
| 申请人 | Zinfandel Pharmaceuticals, Inc. | 发明人 | Roses Allen D. |
| 分类号 | C12Q1/68;C12P19/34;A61P25/28;A61K31/4439 | 主分类号 | C12Q1/68 |
| 代理机构 | Foley & Lardner LLP | 代理人 | Foley & Lardner LLP |
| 主权项 | 1. A method of determining increased risk for development of Alzheimer's disease in a human subject, comprising: (a) detecting the length of a poly-T deletion/insertion polymorphism (DIP) at rs10524523 in intron 6 of the TOMM40 gene from a biological sample containing deoxyribonucleic acid taken from said subject, wherein said poly-T DIP has a length of 19, 20, 21, 22, 23, 26, 27, 28, 29, or 30; (b) correlating the detected poly-T length of 19, 20, 21, 22, 23, 26, 27, 28, 29, or 30 at rs10524523 with an increased risk of development of Alzheimer's disease; and (c) administering an anti-Alzheimer's disease active agent to said subject in an amount effective for treating said subject. | ||
| 地址 | Durham NC US | ||