| 发明名称 |
Crystal of recombinant interferon with altered spatial configuration, three-dimensional structure and uses thereof |
| 摘要 |
This invention provides crystalline recombinant interferon (rSIFN-co (SEQ ID NO: 1)) having (i) the same amino acid sequence as that of human consensus interferon, and (ii) altered three-dimensional structure as compared to IFN-α2b. The interferon of the present invention exhibits enhanced biological activities. The present invention also provides a structural model of said interferon useful for drug screening and/or drug design, and mimetics of said interferon. |
| 申请公布号 |
US8846025(B2) |
申请公布日期 |
2014.09.30 |
| 申请号 |
US201013516947 |
申请日期 |
2010.12.16 |
| 申请人 |
|
发明人 |
Wei Guangwen;Wang Dacheng |
| 分类号 |
A61K38/21;C07K14/56;A61K38/00;G06F19/00;G06F19/16 |
主分类号 |
A61K38/21 |
| 代理机构 |
Law Offices of Albert Wai-Kit Chan, PLLC |
代理人 |
Law Offices of Albert Wai-Kit Chan, PLLC |
| 主权项 |
1. A method of treating a viral disease in a subject, comprising administering to the subject an effective amount of an interferon crystal, wherein said interferon consists of the amino acid sequence of SEQ ID NO: 1, and wherein said crystal has a space group of P3121, and unit cell parameters of a=b=77.92 Å, c=125.935 Å, α=β=90°, and γ=120°. |
| 地址 |
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