COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, E, MÉTODOS PARA MODULAR A ATIVIDADE DE UM CANAL DE ÍON POTÁSSIO EM UM INDIVÍDUO, PARA AUMENTAR O FLUXO DE ÍON POR MEIO DE CANAIS DE POTÁSSIO DEPENDENTES DA VOLTAGEM EM UMA CÉLULA E PARA TRATAR, PREVENIR, INIBIR OU ALIVIAR UM DISTÚRBIO OU CONDIÇÃO DO SISTEMA NERVOSO CENTRAL OU PERIFÉRICO

摘要

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.