发明名称 Functionalized polymers
摘要 This document relates to functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene glycol and related polymers) as well as methods and materials for making and using such functionalized polymers.
申请公布号 US8846941(B2) 申请公布日期 2014.09.30
申请号 US201113324872 申请日期 2011.12.13
申请人 QuiaPEG AB 发明人 Kwiatkowski Marek
分类号 C07F9/06;C07F9/6506;C07F9/572;C07F9/165;C07F9/09;A61K47/48;C07F9/24;C08G81/00;C07F9/6561;C07F9/655 主分类号 C07F9/06
代理机构 Fish & Richardson P.C. 代理人 Fish & Richardson P.C.
主权项 1. A compound comprising a water-soluble, non-peptidic, and non-nucleotidic polymer backbone having at least one terminus covalently bonded to a structure of formula (1): or a salt thereof, wherein: A is the point of covalent bonding to the terminus of the polymer backbone; E is O; K is selected from the group consisting of: alkylene, alkyleneoxyalkylene, and oligomeric alkyleneoxyalkylene; G is selected from the group consisting of: hydrogen, alkoxy, and a hydrophobic separation handle; Z1 and Z2 are independently O; L is a divalent radical of an alkylene; M is a protected carboxyl moiety; R is selected from the group consisting of: a protecting group and a hydrophobic separation handle; R1 is absent or a hydrophobic separation handle; and wherein no more than one of R, R1, and G is a hydrophobic separation handle.
地址 Stockholm SE