Acyl-urea derivatives and uses thereof

摘要

Novel acyl-urea containing compounds, processes of preparing same, compositions containing same and uses thereof in the treatment of neurological diseases and disorders such as epilepsy, neuropathic pain, bipolar disorder, status epilepticus, chemically-induced convulsions and/or seizure disorders, febrile convulsions conditions, metabolic disturbances and a sustenance withdrawal conditions, are provided. Also provided are uses of these and other acyl-urea containing compounds in the treatment of neurological diseases and disorders.

主权项

1. A method of treating a seizure of epilepsy, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound 1-(3,3-dimethyl-butyryl)urea (compound 3, TBU), having the formula: