| 摘要 |
There is provided a compound of formula I;wherein Z is selected from N and CR22, wherein R22 is H or a bond with D;wherein D is selected from a bond, C═O, and linear or branched hydrocarbon groups having a carbon chain of from 1 to 6 carbon atoms, wherein the carbon chain optionally contains an oxy group (═O), an ether (—O—) or thioether (—S—) link,wherein R1 is selected from: triazolyl, imidazolyl, pyrimidinyl radical
wherein each of R2 to R6 is independently selected from —H, NO2, halo, —CN, —N[(C═O)0-1R12][(C═O)0-1R13] and —(CH2)0-1R14,
or two adjacent groups of R2 to R6, together with the carbon atoms to which they are attached, form a ring,
wherein at least one of R2 to R6 is —CN,
wherein
(i) at least one of R2 to R6 is —(CH2)0-1R14, or(ii) at least one of R2 to R6 is —N[(C═O)0-1R12][(C═O)0-1R13], or(iii) at least two adjacent groups of R2 to R6 together with the carbon atoms to which they are attached, form a ring, or(iv) at least one of R2 to R6 is —(CH2)0-1—O—R′14,
wherein R12 and R13 are independently selected from H, linear or branched hydrocarbon groups having a carbon chain of from 1 to 10 carbon atoms,
or together with the atoms to which they are attached, may form a mono or bicyclic ring having from 5 to 14 ring members
wherein R14 is selected from:
aliphatic ring systemsunsubstituted or substituted monocyclic aliphatic heterocycles;unsubstituted or substituted heteroaryl radical, andunsubstituted or substituted phenyl group;the group of formula;
wherein t is 1 or 2
wherein R′14 is a unsubstituted or substituted phenyl group;
wherein each of R7 to R11 is independently selected from —H, NO2, halo, —O—(C1-C6)haloalkyl, (C1-C6)haloalkyl, (C1-C6)alkyl, —CN, —OH, —OPh, —OBn, -Ph, —OSO2NR15R16, —SO2R26, —SO2NR27R28, —O—(C1-C6)alkyl, —(C═O)0-1NR29R30 and —CO(O)0-1R31;
wherein R15 and R16 are independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl optionally contain one or more hetero atoms or groupswherein each of R26 to R31 is independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl optionally contain one or more hetero atoms or groups;
or any pharmaceutically acceptable salts thereof. |
| 主权项 |
1. A compound of formula V wherein each of R2, R3, R5 and R6 is independently selected from —H, NO2, halo, —CN, —NR12R13, and —(CH2)0-1R14; wherein at least one of R2, R3, R5 and R6 is —(CH2)0-1R14; wherein R12 and R13 are independently selected from H, linear or branched hydrocarbon groups having a carbon chain of from 1 to 10 carbon atoms; wherein R14 is an unsubstituted or substituted phenyl group; wherein R4 is —CN; wherein R9 is —OSO2NR15R16; wherein each of R7, R8, R10 and R11 is independently selected from —H, (C1-C6)alkyl, —OH, —OSO2NR15R16, and halo; and wherein R15 and R16 are independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl optionally contain one or more hetero atoms or groups. |
