| 发明名称 | Film-coated and/or granulated calcium-containing compounds and use thereof in pharmaceutical compositions | ||
| 摘要 | Calcium-containing compounds have been at least partly film-coated and/or granulated with a water-soluble substance and a water-soluble polymeric substance and use of such coated compounds in pharmaceutical compositions. The at least partly film-coated and/or granulated calcium-containing compounds have proved suitable for the preparation of tablets having a very high load of elemental calcium and a conveniently small size. A drug load of about 96% or more is obtained in tablets of the invention that have sufficient mechanical and organoleptic properties. | ||
| 申请公布号 | US8846101(B2) | 申请公布日期 | 2014.09.30 |
| 申请号 | US200612085799 | 申请日期 | 2006.12.07 |
| 申请人 | Takeda Nycomed AS | 发明人 | Piene Jan Y. |
| 分类号 | A61K9/14;B23B29/00;B32B9/04;B32B9/00;B05D7/00;A61P43/00 | 主分类号 | A61K9/14 |
| 代理机构 | Choate, Hall & Stewart LLP | 代理人 | Choate, Hall & Stewart LLP ;Lyon Charles E. |
| 主权项 | 1. A method for the preparation of a granulated calcium carbonate, comprising applying a granulating composition to calcium carbonate that is in the form of particles and/or crystals, wherein the granulating composition comprises i) xylitol, and ii) one or more polymeric substances selected from the group consisting of povidones and copovidones, and mixtures thereof, wherein the xylitol and the one or more polymeric substances are dispersed or dissolved in a solvent; wherein the xylitol constitutes from about 2% to about 20% of the total weight of the granulated calcium carbonate, and the one or more polymeric substances constitutes from about 0.09% to about 10% of the total weight of the granulated calcium carbonate. | ||
| 地址 | Asker NO | ||