| 发明名称 | Simian adenovirus 41 and uses thereof | ||
| 摘要 | Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a heterologous gene under the control of regulatory sequences are provided. A cell line which expresses simian adenovirus 41 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | ||
| 申请公布号 | US8846031(B2) | 申请公布日期 | 2014.09.30 |
| 申请号 | US201013321985 | 申请日期 | 2010.05.27 |
| 申请人 | The Trustees of the University of Pennsylvania | 发明人 | Roy Soumitra;Wilson James M.;Vandenberghe Luc H. |
| 分类号 | C12N15/861;C12N7/01;C07K14/075;C12N15/33 | 主分类号 | C12N15/861 |
| 代理机构 | Howson & Howson LLP | 代理人 | Howson & Howson LLP |
| 主权项 | 1. A recombinant adenovirus having a capsid comprising a hexon protein, a penton protein, and a fiber protein, said hexon protein is the SAdV-41 hexon protein with the amino acids 1 to 943 of SEQ ID NO: 11 or amino acids 1 to 943 of SEQ ID NO: 44, and said fiber protein is the fiber protein of SAdV-41.1 with the amino acids 1 to 321 of SEQ ID NO: 21 or the fiber protein of SAdV-41.2 of amino acids 1 to 325 of SEQ ID NO: 54, said capsid encapsidating a heterologous nucleic acid comprising a gene operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell. | ||
| 地址 | Philadelphia PA US | ||