| 发明名称 | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents | ||
| 摘要 | Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogs, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity. | ||
| 申请公布号 | US8846731(B2) | 申请公布日期 | 2014.09.30 |
| 申请号 | US201113267285 | 申请日期 | 2011.10.06 |
| 申请人 | FerroKin Biosciences, Inc. | 发明人 | Tapper Amy E.;Rienhoff, Jr. Hugh Y.;Parent Stephan D.;Andres Patricia;Hanko Jason A.;Zhang Huamin |
| 分类号 | A61K31/426;C07D277/10;C07D277/12 | 主分类号 | A61K31/426 |
| 代理机构 | Choate, Hall & Stewart LLP | 代理人 | Choate, Hall & Stewart LLP ;Chen Fangli;Rearick John P. |
| 主权项 | 1. A solid salt of Formula II:wherein: m is an integer from 0 to 8; n is an integer from 0 to 8; and X is magnesium hydroxide; or a polymorph thereof. | ||
| 地址 | Wayne PA US | ||