| 主权项 |
1. A compound of the formula (I) wherein: R1 is C1-10 alkyl, C3-10 cycloalkyl, 3-10 membered saturated heterocyclic ring, C1-5 alkyl-heterocyclic ring, 5-10 membered mono or bicyclic heteroaryl ring or C1-5 alkyl-heteroaryl ring, wherein each R1 is optionally independently substituted with 1-3 substituents chosen from C1-4 alkyl group, C3-10 cycloalkyl, C1-4 alkoxy, C1-4 alkylsulfonyl, C1-4 acyl, oxo, phenyl, cyano, hydroxyl and halogen; R2 and R3 are C1-4 alkyl or hydrogen with the proviso that both R2 and R3 cannot be hydrogen; or R2 and R3 together with the carbon atom to which they are attached form a 3- to 6-membered cycloalkyl ring or heterocyclic ring; R4 is hydrogen or methyl; R5 is 5 membered heteroaryl ring optionally independently substituted with 1-3 substituents chosen from C1-4 alkyl group, cyano, —C1-8 branched or unbranched alkyl —O—R6, C3-8-cycloalkyl-O—R6, —C1-3 branched or unbranched alkyl —R7 and aryl-R8 each R6 is independently hydrogen, C1-4 alkyl, —C1-4 alkyl-O C1-4 alkyl, or —C1-4 alkyl-OH; R7 is a 5-6 membered heteroaryl ring; R8 is hydroxyl, C1-6 alkoxy, C1-4 alkylsulfonyl, cyano, halogen or C1-4 alkyl L is a bond, —C(O)—, —C(O)—NH— or —SO2—; wherein any carbon atom on the formula (I) or any R substituent listed above is optionally partially or fully halogenated where possible; or a pharmaceutically acceptable salt thereof. |
