Use of compounds isolated from <i>Euphorbia neriifolia </i>for treating cancer and/or thrombocytopenia

摘要

Novel Uses of small molecules, particularly, triterpenoids and ingol diterpenes isolated from Euphorbia neriifolia, are disclosed herein. The triterpenoids are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer; whereas the ingol diterpenes are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating thrombocytopenia.

主权项

1. A method of suppressing the growth of leukemia cells, or inducing the leukemia cells or bone marrow cells to differentiate into megakaryocytes comprising contacting the leukemia cells or bone marrow cells with a sufficient amount of a compound of formula (II), or a pharmaceutically acceptable salt thereofwherein
each R1 and R4 is independently —COCH3; R2 is —COCH3,and
R3 is —CH3,