Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors

摘要

Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

主权项

1. A mono quaternary ammonium compound of formula: wherein A1, A2, A3, A4, and A5 are each carbon; wherein R1, R2, R3, R4, and R5 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, halo, cyano, and nitro; wherein Z1 is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenylene, substituted phenylene, alkoxy, and substituted alkoxy; wherein Z2 is selected from the group consisting of substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylene, substituted arylene, heterocycle, substituted heterocycle, alkoxy and substituted alkoxy; wherein Z3 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocycle, and substituted heterocycle; and wherein X− is an inorganic or organic anion.