发明名称 |
Crystal of a free tricyclic pyrazolopyrimidine derivative |
摘要 |
To provide a crystal of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90. The present invention provides a crystal of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide which inhibits the ATPase activity of HSP90 and which has antitumor activity, a medicament comprising the same, an anticancer agent comprising the same, and the like. |
申请公布号 |
US8846703(B2) |
申请公布日期 |
2014.09.30 |
申请号 |
US201313773419 |
申请日期 |
2013.02.21 |
申请人 |
Daiichi Sankyo Company, Limited |
发明人 |
Ueda Yasusi;Suzuki Nobuyuki;Ohki Hitoshi |
分类号 |
A61K31/55;C07D417/06;C07D495/16 |
主分类号 |
A61K31/55 |
代理机构 |
Christensen O'Connor Johnson Kindness PLLC |
代理人 |
Christensen O'Connor Johnson Kindness PLLC |
主权项 |
1. A crystal of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide represented by the following formula (1): wherein the crystal has the X-ray diffraction pattern shown in FIG. 1, in an X-ray powder diffraction pattern obtained by irradiation with copper Kα radiation (wavelength λ=1.54 angstroms). |
地址 |
Chuo-ku JP |