6,7-dihydro-[1,3,4]thiadiazolo-[3,2-<i>a</i>][1,3]diazepin derivative and pharmaceutical composition containing the same as neuromuscular blocker or skeletal muscle relaxant, and method for the preparation

摘要

The present invention relates to a compound of formula 1 and addition salts thereof, a pharmaceutical composition containing the compound, a method for its preparation as well as the use of the compound as neuro-muscular blocker or skeletal muscle relaxant;;
wherein each symbol is as defined in the Specification.

主权项

1. A compound according to formula 1 or an addition salt thereof: wherein R1, R2, R3 and R4 are each independently selected from hydrogen, halogen, C1-C20-alkyl, C1-C20-haloalkyl, C1-C20-alkoxy, C1-C20-haloalkoxy, aryl, heteroaryl, mercapto, alkylthio, amino, and alkylamino, or wherein R3 and R4 are alicyclic, aryl or heteroaryl ring systems, and are optionally substituted by halogen, amino, C1-C20-alkyl, C1-C20-haloalkyl, C1-C20-alkoxy, C1-C20-haloalkoxy, mercapto, alkylthio, alkylamino, arylthio, heteroarylthio, arylamino or heteroarylamino, and wherein X is O or S.