| 摘要 |
Compositions comprising selenium (e.g., organic selenium (e.g., selenized yeast (e.g., SEL-PLEX))) and methods of using the same (e.g., as a therapeutic and/or prophylactic treatment) are provided. For example, compositions comprising selenium (e.g., organic selenium (e.g., selenized yeast (e.g., SEL-PLEX))) and methods of using the same are provided for treating and/or preventing one or more conditions (e.g., problems) disorders, and/or diseases related to establishing and/or maintaining a pregnancy. Compositions and methods of the invention find use in, among other things, research and clinical (e.g., preventative and therapeutic) applications. |
| 主权项 |
1. A method of treating a female subject that is pregnant or attempting to become pregnant comprising:
a) identifying a female subject that will benefit from the treatment, comprising measuring a level of relaxin gene or gene product expression in said female subject, and identifying the female subject by determining whether the level of expression of relaxin gene or gene product is lower than a normal healthy control female subject, and b) administering an effective amount of a composition comprising a dried, nonviable selenium-enriched yeast to said female subject to enhance-relaxin gene or gene product expression compared to a control female subject not administered said composition, wherein the total selenium content of said yeast comprises two percent or less inorganic selenium. |
