发明名称 |
Epothilone d production process, and its use as cytostatic as well as phytosanitary agents |
摘要 |
Epothilone derivatives are obtained by: (1) cultivation of Sorangium cellulosum DSM 6773 in the presence of an absorption resin; (2) separation of the resin and culture followed by washing with aqueous methanol; (3) eluting the washed resin with methanol and reducing the extract; (4) partitioning the extract between methanol and hexane; (5) reducing the methanolic phase and fractionating it on a Sephadex column, and (6) isolation of the epothilones by chromatography using a methanol/water mixture. Epothilone A is followed by epothilone B, and two further fractions. |
申请公布号 |
HU229833(B1) |
申请公布日期 |
2014.09.29 |
申请号 |
HU20000000497 |
申请日期 |
1997.11.18 |
申请人 |
GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH. |
发明人 |
GERTH KLAUS;HOEFLE GERHARD;REICHENBACH HANS;STEINMETZ HEINRICH |
分类号 |
C07D417/06;A01N43/78;A01N43/90;A01N63/02;A61K31/425;A61K31/427;A61P35/00;C07D493/04;C12P1/04;C12P17/08;C12P17/16;C12P17/18;C12R1/01 |
主分类号 |
C07D417/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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