发明名称 LIPOSOME SUSPENSION STABILISER AND METHOD FOR PRODUCTION THEREOF
摘要 FIELD: chemistry.SUBSTANCE: stabiliser includes modified chitosan which is obtained by modifying chitosan particles located in an emulsion of an organic solvent - water, with pH 6.0-6.5, by first reacting a mixture consisting of a carboxylic acid in an organic solvent and a condensing agent, and then with an organic base, wherein the carboxylic acid used is either palmitic acid or stearic acid or dodecanoic acid, the condensing agent used is a mixture of hydroxysuccinimide and an aliphatic carbodiimide or formaldehyde and an aliphatic isocyanide, and the organic base used is triethylamine.EFFECT: effective liposome composition stabiliser which can be obtained using a simple method.8 cl, 3 tbl, 5 ex, 7 dwg
申请公布号 RU2529179(C1) 申请公布日期 2014.09.27
申请号 RU20130118961 申请日期 2013.04.23
申请人 OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOST'JU "URAL'SKIJ TSENTR BIOFARMATSEVTICHESKIKH TEKHNOLOGIJ" 发明人 PONOMAREV VLADISLAV SERGEEVICH;MIRONOV MAKSIM ANATOL'EVICH;TOKAREVA MARIJA IGOREVNA;IVANTSOVA MARIJA NIKOLAEVNA;RUSINOV VLADIMIR LEONIDOVICH;MATERN ANATOLIJ IVANOVICH;CHARUSHIN VALERIJ NIKOLAEVICH;CHUPAKHIN OLEG NIKOLAEVICH
分类号 A61K31/722;A61K9/127;C08B37/08 主分类号 A61K31/722
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