Method for activation and conjugation of biomolecules

摘要

Disclosed is a method for producing a biomolecule conjugate comprising the steps of - activating the biomolecule by contact with an activating agent; - removing the activating agent; and - conjugating the biomolecule by reacting the biomolecule with an activated polymer; wherein the steps of the method are integrated into a single unit operation and the single unit operation is an integrated tangential flow filtration system.