1,5-diphenyl-penta-1,4-dien-3-one compounds

摘要

Provided are 1,5-diphenylpenta-1,4-dien-3-one derivative compounds of Formula (I), (II), or (III) where the variables are as described herein. Particularly preferred are compounds of formula (III) wherein at least one of R1, R2, R3 , R4 ,R5 ,R1’, R2’, R3’, R4’and R5’is RdS(O)2-O-, (Rd)2P(O)-O-, or (RdO)2P(O)-O-. The compounds deactivate Signal Transducer and Activator of Transcription (STAT) proteins. These compounds may be used in the treatment of cancer, inflammatory diseases, or autoimmune diseases.