| 发明名称 |
TREATMENT OF HEART DISEASE BY INHIBITION OF THE ACTION OF RIBOSOMAL S6 KINASE 3 (RSK3) |
| 摘要 |
The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAPβ, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAPβ binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3. |
| 申请公布号 |
US2014286928(A1) |
申请公布日期 |
2014.09.25 |
| 申请号 |
US201414213583 |
申请日期 |
2014.03.14 |
| 申请人 |
ANCHORED RSK3 INHIBITORS, LLC |
发明人 |
KAPILOFF Michael S.;LI Jinliang;KRITZER Michael;PASSARIELLO Catherine;DODGE-KAFKA Kimberly |
| 分类号 |
A61K38/45;A61K31/519;A61K38/17;A61K31/7048 |
主分类号 |
A61K38/45 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAPβ. |
| 地址 |
Miami Beach FL US |
