COMPOSITIONS AND METHODS OF NUCLEIC ACID-TARGETING NUCLEIC ACIDS
摘要
This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.
申请公布号
WO2014150624(A1)
申请公布日期
2014.09.25
申请号
WO2014US23828
申请日期
2014.03.12
申请人
CARIBOU BIOSCIENCES, INC.
发明人
MAY, ANDREW, PAUL;HAURWITZ, RACHEL, E.;DOUDNA, JENNIFER, A.;BERGER, JAMES, M.;CARTER, MATTHEW, MERRILL;DONOHOUE, PAUL