METHODS FOR PRODUCING FABS AND BI-SPECIFIC ANTIBODIES
摘要
The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain- light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1 /CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
申请公布号
WO2014150973(A1)
申请公布日期
2014.09.25
申请号
WO2014US24688
申请日期
2014.03.12
申请人
ELI LILLY AND COMPANY;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人
DEMAREST, STEPHEN J.;KUHLMAN, BRIAN ARTHUR;LEWIS, STEVEN MORGAN;TOUGHIRI, RAHELE;WU, XIUFENG
