Oral Tablet Formulation Consisting Of Fixed Combination Of Rosuvastatin And Ezetimibe For Treatment Of Hyperlipidemia And Cardiovascular Diseases

摘要

The present invention is an orally consumed fixed combination formulation of both rosuvastatin and ezetimibe in one tablet that is expected to have the same Area Under Curve as two active ingredients taken together individually orally, and pharmaceutically acceptable additives suitable for the preparation. In preferred embodiments of this invention, the rosuvastatin is in the form of rosuvastatin calcium and the pharmaceutically acceptable additives are selected from diluents, disintegrants, glidants, lubric ants, colorants and combinations thereof.

主权项

1. A solid dosage form of rosuvastatin and ezetimibe combined in one table comprising:
rosuvastatin and egzetimibe in a ratio of 0.5:1, 1:1 or 2:1, wherein rosuvastatin is formulated with microcrystalline cellulose and ezetimibe is mounted on lactose; and pharmaceutically acceptable additives suitable for the preparation of solid dosage forms of a combination of rosuvastatin and ezetimibe.