Implantable Devices for Delivery of Bioactive Agents

摘要

An implantable delivery device and method for utilizing the device to delivery a bioactive agent to a subject in need thereof is described. The device includes a pattern of structures fabricated on a surface of the device to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The device may be located adjacent tissue such as an endovascular implant or a perivascular implant, and may deliver the bioactive agent without triggering an immune or foreign body response to the bioactive agent.

主权项

1. An implantable delivery device for delivery of a bioactive agent to a subject, the device comprising
a plurality of nanostructures fabricated on a surface of the implantable delivery device, the nanostructures being arranged in a predetermined pattern; and a bioactive agent within or on the implantable delivery device.