VACCINE PREPARATION CONTAINING TRIFUNCTIONAL ANTIBODIES WITH ANTIGEN IMMUNOGENICITY ENHANCER PROPERTIES

摘要

The present invention refers to a pharmaceutical composition containing trifunctional bispecific and/or trispecific antibodies being capable of binding to a specific target antigen(s) for use in a method of immunizing mammals against diseases in which said target antigen(s) is (are) involved, and further to a pharmaceutical composition containing trifunctional bispecific and/or trispecific antibodies being capable of binding to (a) specific target antigen (s) which is (are) involved in a disease of a mammal, specifically a human.

主权项

1. A method of immunizing a mammal subject, comprising administering to said subject a pharmaceutically effective amount of pharmaceutical composition comprising
a pharmaceutically effective amount of a trifunctional bispecific and/or trispecific antibody having the following properties:
(a) binding to T cell via CD3 and activating said T cell;(b) binding to a target antigen which is present in solubilized form or in cryopreserved form or in particulate form;(c) binding via its Fc-portion or by a third specificity (in the case of trispecific antibodies) to Fcγ-receptor type I, IIa and/or III positive cells and initiating the production of cytokines or upregulation of costimulatory signals or a combination thereof and thereby activating T cells;(d) initiating interferon-gamma-accompanied TH1-biased T cell responses and humoral immune responses; an immunologically effective amount of said target antigen and optionally one or more further antigens in an immunologically effective amount wherein said antigens are present in solubilized or cryopreserved or particulate form; and a pharmaceutically acceptable carrier,
to evoke a cell-mediated or a humoral immune response or a combination thereof against said target antigen and said optionally one or more further antigens to immunize said mammal subject against said one or more antigens.