Methods of Treating Cardiovascular Diseases and Predicting the Efficacy of Exercise Therapy

摘要

Methods of treating a subject having a cardiovascular disease, selecting a therapy for a subject having a cardiovascular disease, identifying a subject having a cardiovascular disease that will benefit or not benefit from exercise therapy, determining whether a subject having a cardiovascular disease should begin, continue, not begin, discontinue, or avoid exercise therapy, determining whether a subject having a cardiovascular disease should continue, discontinue, or avoid exercise therapy, reducing the risk of an adverse outcome (e.g., death) in a subject having a cardiovascular disease, and predicting the efficacy of exercise therapy in a subject having a cardiovascular disease. These methods include determining a level of soluble ST2 in a subject.

主权项

1. A method of treating a subject having a cardiovascular disease, the method comprising:
a) determining a level of soluble ST2 in a biological sample from the subject; b) identifying a subject that has a decreased level of soluble ST2 in the biological sample compared to a risk or efficacy reference level of soluble ST2; and c) selecting the identified subject for exercise therapy.