发明名称 |
TREATMENT OF RED BLOOD CELLS |
摘要 |
Compositions and methods for treating red blood cells are disclosed. The methods include contacting a red blood cell sample ex vivo with an amount of nitric oxide or a nitric oxide-releasing compound sufficient to convert at least a portion of the extracellular ferrous hemoglobin present in the red blood cell sample to ferric hemoglobin. Red blood cells administered to a mammal following the ex vivo treatment have reduced adverse effects on the mammal to which they are administered. |
申请公布号 |
US2014286921(A1) |
申请公布日期 |
2014.09.25 |
申请号 |
US201214356221 |
申请日期 |
2012.11.06 |
申请人 |
The General Hospital Corporation |
发明人 |
Zapol Warren M.;Yu Binglan |
分类号 |
A61K33/00;A61K35/18 |
主分类号 |
A61K33/00 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a red blood cell sample, the method comprising contacting a red blood cell sample ex vivo with an amount of nitric oxide or a nitric oxide-releasing compound sufficient to convert at least a portion of the extracellular ferrous hemoglobin present in the red blood cell sample to ferric hemoglobin. |
地址 |
Boston MA US |