ANDROGEN RECEPTOR DOWN-REGULATING AGENTS AND USES THEREOF
摘要
The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional AR.
申请公布号
CA2904170(A1)
申请公布日期
2014.09.25
申请号
CA20142904170
申请日期
2014.03.14
申请人
UNIVERSITY OF MARYLAND, BALTIMORE;UNIVERSITY OF MARYLAND EASTERN SHORE;THOMAS JEFFERSON UNIVERSITY
发明人
NJAR, VINCENT C.O.;GEDIYA, LALJI K.;PURUSHOTTAMACHAR, PURANIK;GODBOLE, ABHIJIT;KWEGYIR-AFFUL, ANDREW;VASAITIS, TADAS