Synthetic and Purification Methods for Phosphaplatin Compounds and Uses Thereof

摘要

This application discloses novel methods and processes for preparation and purification of phosphaplatin compounds. The improvements of the synthetic methods and purification processes include, but are not limited to, efficient and reproducible large-scale preparation of these useful pharmaceutical agents in high quality and good yield.

主权项

1. A method of preparing a monomeric platinum pyrophosphate complex, or a salt thereof, comprising: mixing a platinum dihalide compound with a pyrophosphate salt in a solvent system comprising water and at least one wetting agent, maintaining a reaction mixture wherein the platinum dihalide compound reacts with the pyrophosphate salt to form the monomeric platinum pyrophosphate complex; precipitating out the monomeric platinum pyrophosphate complex; and isolating the monomeric platinum complex from the reaction mixture.