NANOPARTICLE-COATED MEDICAL DEVICES AND FORMULATIONS FOR TREATING VASCULAR DISEASE

摘要

PROBLEM TO BE SOLVED: To provide a nano particle-containing formulation with enhanced endothelium targeting, nanoparticle-coated medical devices and the methods of using each for the treatment of vascular disease.SOLUTION: A formulation comprises a first population of nanoparticles having a density similar to that of blood and a second population of nanoparticles having a density different from that of blood modified to operatively couple to a surface of the first population of nanoparticles, wherein when the second population of nanoparticles is coupled to the first population of nanoparticles a supraassembly having a density different from that of blood is formed. The first population of nanoparticles contains one or more bioactive agents encapsulated within the first population of nanoparticles, adhered to a surface thereof or integrated into the structure thereof.