| 发明名称 |
NOVEL BINDING PROTEINS FOR PCSK9 |
| 摘要 |
The present disclosure relates to novel lipocalin muteins which bind to PCSK9. The disclosure also provides corresponding nucleic acid molecules encoding lipocalin muteins and methods for producing lipocalin muteins as well as their encoding nucleic acid molecules. |
| 申请公布号 |
US2014288008(A1) |
申请公布日期 |
2014.09.25 |
| 申请号 |
US201414208629 |
申请日期 |
2014.03.13 |
| 申请人 |
Pieris AG ;Daiichi Sankyo Company, Limited |
发明人 |
MATSCHINER GABRIELE;ROTHE CHRISTINE;HOHLBAUM ANDREAS;ALLERSDORFER ANDREA;AIBA RACHIDA SIHAM BEL;HINNER MARLON;WIEDENMANN ALEXANDER;YAMAGUCHI SHINJI;ABURATANI TAKAHIDE;HASHIMOTO RYUJI;TAKAHASHI TOHRU;NAGASAKI CHIKAKO;NARA FUTOSHI;NISHIZAWA TOMOHIRO |
| 分类号 |
C07K14/47;G01N33/573 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A mutein of human tear lipocalin, wherein the mutein comprises:
(a) a mutated amino acid residue at any one or more of the sequence positions 26-34, 56-58, 80, 83, 104-106 and 108 of the linear polypeptide sequence of the mature human tear lipocalin, and (b) a mutated amino acid residue at any one or more of the sequence positions 61, 101, 111, 114 and 153 of the linear polypeptide sequence of the mature human tear lipocalin, and wherein the mutein binds specifically to PCSK9. |
| 地址 |
Freising-Weihenstephan DE |
