GINGIPAIN INHIBITORY PROPEPTIDES

摘要

The disclosure relates to compounds, peptides or peptidomimetics that inhibit, reduce or prevent protease activity and the use of these compounds, peptides or peptidomimetics to treat or prevent a condition. In particular the condition may be periodontal disease. The protease activity may be activity of a gingipain. The compounds, peptides or peptidomimetics of the invention may also be used in assays for the identification of protease inhibitors.

主权项

1. A peptide or peptidomimetic for inhibiting, reducing or preventing the activity of a bacterial enzyme, the compound, peptide or peptidomimetic consisting essentially of an amino acid sequence that is selected from the group consisting of SEQ ID NO: 1 to 28 and conservative substitutions therein.